Methods for diagnosing cancer
AssigneeIncyte Corporation
InventorsPreeti G. LAL, Janice Au-Young, Roopa Reddy, Lynn E. Murry, Preete Mathur
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Abstract
The invention provides cDNAs which encodes a signal peptide-containing proteins. It also provides for the use of a cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.
Claims21
-20. (canceled)
A method of diagnosing the presence of cancer in a subject by detecting the expression of a signal peptide-containing protein, wherein the method comprises:
- (a) providing a biological sample from the subject;
- (b) contacting the biological sample with a polypeptide which specifically binds to antibodies present in the biological sample, wherein the polypeptide is selected from the group consisting of:
- (i) a polypeptide comprising the amino acid sequence of SEQ ID NO:16, and
- (ii) a polypeptide having an amino acid sequence at least about 90% identical to the amino acid sequence of SEQ ID NO:16,
- (c) detecting the presence of bound polypeptide in the biological sample;
- (d) comparing the presence of bound polypeptide in the biological sample with the presence of bound polypeptide in a control sample;
- (e) wherein a higher presence in the biological sample as compared to the control sample is correlated with the presence of cancer.
A method of diagnosing the presence of cancer in a subject by detecting the expression of a signal peptide-containing protein, wherein the method comprises:
- (a) providing a biological sample from the subject;
- (b) contacting the biological sample with an antibody which specifically binds to a signal peptide-containing protein present in the biological sample, wherein the antibody specifically binds to a polypeptide selected from the group consisting of:
- (i) a polypeptide comprising the amino acid sequence of SEQ ID NO:16, and
- (ii) a polypeptide having an amino acid sequence at least about 90% identical to the amino acid sequence of SEQ ID NO:16,
- (c) detecting the presence of bound antibody in the biological sample;
- (d) comparing the presence of bound antibody in the biological sample with the presence of bound antibody in a control sample;
- (e) wherein a higher presence in the biological sample as compared to the control sample is correlated with the presence of cancer.
A method of diagnosing the presence of cancer in a subject by detecting the expression of a signal peptide-containing protein, wherein the method comprises:
- (a) providing a biological sample from the subject;
- (b) contacting the biological sample with a nucleic acid probe at least 18 nucleic acids in length and having at least 50% sequence identity with the sequence of SEQ ID NO:
- 17;
- (c) detecting the presence of a hybridization complex in the biological sample;
- (d) comparing the presence of hybridization complex in the biological sample with the presence of hybridization complex in a control sample;
- (e) wherein a higher amount of hybridization complex in the biological sample is correlated with cancer.
Dependencies are inferred from the claim text.