Enhancers of induced pluripotent stem cell reprogramming

A method of making an induced pluripotent stem cell comprising:

• (i) contacting a non-pluripotent cell with a compound having the formula:
• wherein,
• X1 is C(R12) or N;
• X2 is C(R4) or N;
• X3 is C(R5) or N;
• R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are independently selected from hydrogen, halogen, —CN, —NO2, —NH2, —CF3, —CCl3, —OH, —SH, —SO3H, —C(O)OH, —C(O)NH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, wherein R2 and R3 are optionally joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• (ii) after step (i), allowing said non-pluripotent cell to divide thereby forming said induced pluripotent stem cell.

A composition comprising:

• (i) an Oct4 recombinant protein, a Sox2 recombinant protein, a Nanog recombinant protein, a cMyc recombinant protein, a Lin28 recombinant protein, a Klf4 recombinant protein, a nucleic acid encoding an Oct4 protein, a nucleic acid encoding a Sox2 protein, a nucleic acid encoding a Nanog protein, a nucleic acid encoding a cMyc protein, a nucleic acid encoding a Lin28 protein, a nucleic acid encoding a Klf4 protein, a Sox2 expression inducer, a cMyc expression inducer, a Lin28 expression inducer, or a Klf4 expression inducer;
• and
• (ii) a compound having the formula:
• wherein,
• X1 is C(R12) or N;
• X2 is C(R4) or N;
• X3 is C(R5) or N;
• R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are independently selected from hydrogen, halogen, —CN, —NO2, —NH2, —CF3, —CCl3, —OH, —SH, —SO3H, —C(O)OH, —C(O)NH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, wherein R2 and R3 are optionally joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl.

A mixture comprising a cell and a compound having the formula:

• wherein,
• X1 is C(R12) or N;
• X2 is C(R4) or N;
• X3 is C(R5) or N;
• R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are independently selected from hydrogen, halogen, —CN, —NO2, —NH2, —CF3, —CCl3, —OH, —SH, —SO3H, —C(O)OH, —C(O)NH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, wherein R2 and R3 are optionally joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl.