Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates
AssigneeImmunoGen, Inc.
InventorsRavi V.J. CHARI, Walter A. BLATTLER
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Abstract
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
Claims3
1-375. (canceled)
A cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker,
- wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically binds to a target cell, wherein at least a constant region of the antibody, single chain antibody or antibody fragment comprises a human antibody sequence.
A method for targeting maytansinoids to a selected cell population in vivo, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population,
- wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically binds to a target cell, wherein at least a constant region of the antibody, single chain antibody or antibody fragment comprises a human antibody sequence.
Dependencies are inferred from the claim text.