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US 2014/0154795 A1Published application
Bioreactor using acoustic standing waves
AssigneeFloDesign Sonics, Inc.
InventorsBart Lipkens, Louis Masi, Stanley Kowalski, III, Walter M. Presz, JR., Jason Dionne, Brian Dutra, Ari Mercado, Thomas J. Kennedy, III, Arthur Martin
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Abstract
A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
Claims19
A system comprising:
- a bioreactor including a reaction vessel, an agitator, a feed inlet, and an outlet;
- and
- a filtering device, comprising:
- an inlet fluidly connected to the bioreactor outlet for receiving fluid from the bioreactor;
- a flow chamber through which the fluid can flow;
- and
- a sleeve surrounding the flow chamber, the sleeve including at least one ultrasonic transducer and a reflector located opposite the at least one ultrasonic transducer, the at least one ultrasonic transducer being driven to produce a multi-dimensional standing wave in the flow chamber.
4 more elements
Dependencies are inferred from the claim text.