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US 2014/0154773 A1Published application
Thrombin solution and methods of use thereof
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsRoberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
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Abstract
Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
Claims20
A method for lyophilization of an aqueous thrombin solution, the method comprising:
- providing the aqueous thrombin solution comprising about 1 to less than about 4.6% (w/v) of a saccharide or sugar alcohol;
- at least about 0.7 to lower than about 1.75% (w/v) sodium chloride;
- about 0.2 to about 3% (w/v) albumin;
- calcium chloride;
- and sodium acetate;
- and
- lyophilizing the aqueous thrombin solution.
4 more elements
An aqueous thrombin solution comprising:
- about 1 to less than about 4.6% (w/v) saccharide or sugar alcohol;
- at least about 0.7 to lower than about 1.75% (w/v) sodium chloride;
- about 0.2 to about 3% (w/v) albumin;
- calcium chloride;
- and
- sodium acetate.
3 more elements
Dependencies are inferred from the claim text.