Cell and biofactor printable biopapers
AssigneeThe Government of the United States of America, as represented by the Secretary of the Navy
InventorsBradley R. Ringeisen, Russell Kirk Pirlo, Peter K. Wu
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Abstract
Disclosed herein is a structure having: a porous polymeric film permeated by a first extracellular matrix material; and a topcoat layer comprising a second extracellular matrix gel disposed on the film. Also disclosed herein is a method of: providing a porous polymeric film; permeating the film with a first extracellular matrix material; and applying a topcoat layer of a second extracellular matrix material to the film. Also disclosed herein is a method of: laser-machining holes through a film comprising collagen to form a web-like structure.
Claims8
A method comprising:
- providing a structure comprising:
- a porous polymeric film permeated by a first extracellular matrix material;
- and
- a topcoat layer comprising a second extracellular matrix gel disposed on the film;
- and
- placing living cells on or within the topcoat layer to form a cell-seeded structure.
A method comprising:
- laser-machining holes through a film comprising collagen to form a web-like structure.
Dependencies are inferred from the claim text.