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US 2014/0154662 A1Published application
Apparatus and process for growing a heart valve in three-dimensions
AssigneeThe Regents of the University of California
InventorsSeyedhamed Alavi, Arash Kheradvar
Life of this patent
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Abstract
The present invention relates to a heart valve and, more particularly, to a mold and process shaping and securing cells and tissue layers as they are grown in three-dimensions into a heart valve.
Claims22
An apparatus for growing a heart valve in vitro, comprising:
- a first part, the first part having a heart valve-shaped protrusion with a plurality of cusps that are formed to mimic the shape of a heart valve leaflet;
- a second part, the second part having recesses that are formed to receive the heart valve-shaped protrusion.
A method for growing a heart valve in vitro, comprising acts of:
- positioning a scaffold between a first part and a second part, the first part having a heart valve-shaped protrusion with a plurality of cusps that are formed to mimic the shape of a heart valve leaflet and the second part having a recess that is formed to receive the heart valve-shaped protrusion;
- closing the first and second parts around the scaffold such that the scaffold is enclosed within the first and second parts;
- introducing a first solution of cells, through an injection hole, onto the scaffold;
- and
- incubating the first solution of cells until a first tissue layer forms.
2 more elements
Dependencies are inferred from the claim text.