Methods to treat cancer using cyclosporine and cyclosporine derivatives
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJohn DITTMAR, Rodney J. ROTHSTEIN, Robert J.D. REID, Ramon PARSONS, Matthew MAURER, Jacquelyn SHAW
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Abstract
Methods to treat certain types of cancer with cyclophilin inhibitors.
Claims18
A method to treat cancer in a subject in need of treatment therefor, the method comprising contacting a PTEN negative cancer in the subject with an agent which inhibits cyclophilin activity.
A method to reduce growth of a cancer cell in a subject in need of treatment therefor, the method comprising:
- contacting a PTEN negative cancer cell in the subject with a therapeutic amount of an agent which inhibits cyclophilin activity, whereby the growth of the cancer is reduced compared to PTEN positive cancer cells.
A method to induce apoptosis of a cancer cell in a subject in need of treatment therefor, the method comprising:
- contacting a PTEN negative cancer cell in the subject with a therapeutic amount of an agent which inhibits cyclophilin activity, whereby apoptosis of the cancer cell is induced and the subject is treated.
A method to treat cancer in a subject in need of treatment therefor, the method comprising:
- administering to a subject diagnosed with a PTEN negative cancer a therapeutic amount of an agent which inhibits cyclophilin activity, whereby the cancer is treated.
The method of claim -4, wherein the agent which inhibits cyclophilin activity is sanglifehrin.
Dependencies are inferred from the claim text.