Novel pharmaceutical composition

The pharmaceutical tablet comprising:

• a) an amount of a drug, which is N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, selected from:
• about 0.5635 mg, about 1.127 mg, and about 2.254 mg;
• wherein,
• b) at least 50% of the drug particles have a particle size of 30 micron or less.

A process for preparing pharmaceutical tablets containing an amount of a drug, which is N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, in an amount selected from:

• about 0.5635 mg, about 1.127 mg, and about 2.254 mg, which process comprises the steps of;
• admixing:
• N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate,
• one or more excipients, where the excipients are substantially free of water, and
• further excipients,
• to form a mixture;
• and
• compressing the mixture into tablets;
• provided:
• each tablet contains N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxidein solvate in an amount selected from:
• about 0.5635 mg, about 1.127 mg, and about 2.254 mg;
• and
• at least 50% of the drug particles have a particle size of 30 micron or less.