Hydrophobic Preparations
AssigneeVaxcine Ltd.
InventorRoger New
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Abstract
The present invention relates to preparations of substances in hydrophobic solvents in which they would not normally be soluble and to processes for obtaining these preparations. In particular, the invention relates to preparations of hydrophilic species in hydrophobic solvents such as oils. The use of these preparations as vaccines and in pharmaceutical compositions is also described.
Claims24
A single phase hydrophobic preparation comprising a hydrophilic species, and an amphiphilic component comprising sodium docusate, a phospholipid and a nonionic amphiphile, in an oil phase, wherein the moieties of the hydrophilic species are surrounded by the amphiphilic component with the hydrophilic head groups of the amphiphilic component orientated towards the hydrophilic species and wherein there is no chemical interaction between the amphiphilic component and the hydrophilic species;
- characterised in that said non-ionic amphiphile has a lipophilic chain comprising 10 to 20 carbons, and a head group comprising 2 to 10 oxyethylene groups or 1 to 3 hydroxyl groups.
A method of manufacture of a hydrophobic preparation containing a hydrophilic species which includes the following steps:
- (i) mixing a solution of sodium docusate, a phospholipid and a non-ionic amphiphile dissolved in a hydrophobic solvent with a solution of a hydrophilic species dissolved in an aqueous phase to form an emulsion;
- (ii) removing the aqueous phase and hydrophobic solvent;
- and
- (iii) adding an oil phase to the dry residue obtained in (ii).
Dependencies are inferred from the claim text.