Multiple antigen presenting immunogenic composition, and methods and uses thereof
AssigneeChildren's Medical Center Corporation
InventorsRichard Malley, Yingjie Lu, Fan Zhang
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Abstract
The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
Claims27
An immunogenic composition comprising a polymer, at least one antigen, and at least one complementary affinity-molecule pair comprising:
- a first affinity molecule associated with the polymer, and
- a complementary affinity molecule associated with the antigen,
- wherein the first affinity molecule associates with the complementary affinity molecule to link the antigen and the polymer.
2-78. (canceled)
A kit comprising:
- a container comprising a polysaccharide cross-linked with a plurality of first affinity molecules;
- and
- a container comprising a complementary affinity molecule which associates with the first affinity molecule, wherein the complementary affinity molecule associates with an antigen, and optionally a means to attach the complementary affinity molecule to the antigen;
- or
- a container comprising an expression vector for expressing an antigen-complementary affinity molecule fusion protein.
Dependencies are inferred from the claim text.