Targeted nanovectors and their use for treatment of brain tumors

A method of treating a brain tumor in a subject, wherein the method comprises:

• administering a therapeutic composition to the subject, wherein the therapeutic composition comprises:
• a nanovector;
• an active agent associated with the nanovector, wherein the active agent has activity against brain tumor cells, and
• a targeting agent associated with the nanovector, wherein the targeting agent has recognition activity for a marker of the brain tumor cells.

A method of formulating a therapeutic composition for treating a brain tumor in a subject, wherein the method comprises:

• isolating brain tumor cells from the subject;
• determining expression levels of one or more markers of the brain tumor cells;
• and
• formulating the therapeutic composition, wherein the formulated therapeutic composition comprises:
• a nanovector;
• an active agent associated with the nanovector;
• and
• a targeting agent associated with the nanovector, wherein the targeting agent has recognition activity for a marker of the brain tumor cells, and wherein the targeting agent is selected based on the determined expression levels of the one or more markers of the brain tumor cells.