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US 2014/0154266 A1Published application
Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
AssigneeBerg Pharma LLC
InventorsNiven Rajin Narain, Rangaprasad Sarangarajan, Vivek K. Vishnudas, Enxuan Jing
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Abstract
The invention provides methods of treatment of metabolic syndrome with HSP90 inhibitors, particularly HSP90β inhibitors. The invention provides methods of diagnosis and monitoring of metabolic syndrome using HSP90, particularly HSP90β, expression and activity level.
Claims51
A method of treating a metabolic syndrome in a subject, comprising administering to the subject an HSP90 modulator, thereby treating the metabolic syndrome in the subject.
A method of diagnosing a metabolic syndrome in a subject comprising:
- a) determining a level of HSP90β expression or activity in a sample from the subject;
- and
- b) comparing the level of HSP90β expression or activity in the sample from the subject to a control sample, wherein increased expression or activity of HSP90β in the subject sample as compared to the control sample is indicative of a metabolic disorder in the subject.
A method of monitoring a metabolic syndrome in a subject comprising:
- a) obtaining a sample from the subject at a first time point and at a second time point;
- b) determining a level of HSP90β expression or activity at the first time point and the second time point;
- and
- c) comparing the level of HSP90β expression or activity at the first time point to the level of HSP90β expression or activity at the second time point, wherein a change in the level of HSP90β expression or activity at the second time point relative to the first time point is indicative of a change in the metabolic syndrome in the subject.
1 more element
Dependencies are inferred from the claim text.