Arterivirus
AssigneeUniversity of Manitoba
InventorsMarjolein Kikkert, Brian Leonard Mark, Puck Bertyne van Kasteren, Terrence William James, Eric John Snijder
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Abstract
The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes.
Claims20
A replication-competent Arterivirus, characterized in that said virus has a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2.
A PLP2-ubiquitin complex comprising ubiquitin and at least the PLP2 domain of nsp2 of an Arterivirus, wherein said PLP2 domain is covalently bound to said ubiquitin, or a PLP2-ISG15 complex comprising ISG15 and at least the PLP2 domain of nsp2 of an Arterivirus, wherein said PLP2 domain is covalently bound to said ISG15.
Dependencies are inferred from the claim text.