Anti-il1alpha/beta dual variable domain immunoglobulin and uses thereof
AssigneeAbbVie Inc.
InventorsChengbin Wu, Tariq Ghayur, Richard W. Dixon, Jochen G. Salfeld
Life of this patent
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Abstract
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
Claims39
A binding protein comprising a polypeptide chain, wherein said polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain, VD2 is a second variable domain, C is a constant domain, X1 represents an amino acid or polypeptide, X2 represents an Fc region and n is 0 or 1, wherein said binding protein is capable of binding IL-1α and IL-1β.
3-5. (canceled)
A binding protein comprising a polypeptide chain, wherein said polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first heavy chain variable domain, VD2 is a second heavy chain variable domain, C is a heavy chain constant domain, X1 is a linker with the proviso that it is not CH1, and X2 is an Fc region.
13-15. (canceled)
(canceled)
A binding protein comprising four polypeptide chains, wherein:
- a first polypeptide chain and a second polypeptide chain each comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain, VD2 is a second variable domain, C is a constant domain, X1 is a linker with the proviso that it is not a constant domain, X2 is an Fc region, and n is 0 or 1;
- and
- a third polypeptide chain and a fourth polypeptide chain each comprises VD1-(X1)n-VD2-C, wherein VD1 is a first variable domain, VD2 is a second variable domain, C is a constant domain, and X1 is a linker with the proviso that it is not a constant domain, and n is 0 or 1;
- wherein either or each of VD 1 and VD2 of said polypeptide chains is a non-immunoglobulin variable domain;
- and
- wherein said four polypeptide chains of said binding protein form four functional binding domains, wherein said binding protein is capable of binding IL-1α and IL-1β.
31-41. (canceled)
An isolated nucleic acid comprising a coding sequence for a polypeptide chain comprising the structure VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a variable domain, VD2 is a second variable domain, C is a constant domain, X1 is a linker with the proviso that it is not a constant domain, X2 is an Fc region, and n is 0 or 1, wherein said binding protein is capable of binding IL-1α and IL-1β.
(canceled)
46-47. (canceled)
49-68. (canceled)
70-72. (canceled)
(canceled)
Dependencies are inferred from the claim text.