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US 2014/0154252 A1Published application
Single-chain multivalent binding proteins with effector function
AssigneeEmergent Product Development Seattle, LLC
InventorsPETER ARMSTRONG THOMPSON, JEFFREY A. LEDBETTER, MARTHA SUSAN HAYDEN-LEDBETTER, WILLIAM BRADY
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Abstract
Variations on the structural themes for multivalent binding molecules with effector function, or scorpions, will be apparent to those of skill in the art upon review of the present disclosure, and such variant structures are within the scope of the invention.
Claims49
A multivalent binding protein comprising, from amino to carboxyl terminus:
- a) a first binding domain;
- b) a constant sub-region comprising an immunoglobulin hinge region, CH2 domain and a CH3 domain;
- c) a C-terminus linker peptide;
- and
- d) a second binding domain,
- wherein the binding protein is capable of cross-linking two or more targets.
3 more elements
Dependencies are inferred from the claim text.