US 2014/0154246 A1 · CAI-BASED SYSTEMS AND METHODS FOR THE LOCALIZED TREATMENT OF OCULAR AND OTHER DISEASES

Abstract

The subject invention provides CAI compounds and formulations thereof, and methods for their use in the localized treatment of non-life threatening diseases. Formulations of CAI compounds of the subject invention include CAI free base and CAI prodrug microcrystallines, microparticles, emulsions, and the like. The subject invention further provides methods for treating non-life threatening diseases using the CAI compounds of the invention (i.e., novel delivery systems and combination therapies), that are effective and are associated with little or no adverse side effects.

Claims30

Dependent claims

A method for treating a patient suffering from age-related macular degeneration or diabetic retinopathy comprising:

(a) diagnosing age-related macular degeneration, diabetic retinopathy- or symptom thereof in a patient;
and
(b) ocularly administering to said patient a sterile, aqueous suspension formulation free of organic solvents comprising a therapeutically effective amount of suspended solid microparticulates of CAI (5-amino-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4-carboxamide) free base form, wherein the effective amount comprises a dose of 0.1 to 30 mg/ml of CAI in formulation with hydroxypropyl β-cyclodextrin.

Dependencies are inferred from the claim text.

Facts

Application

14/174,080Filed 6 Feb 2014

Priority

24 Sep 2004

Published

5 Jun 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification38 codes

A61K 31/4192
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2,3-Triazoles
A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 31/7088
Carbohydrates; Sugars; Derivatives thereof: compounds having three or more nucleosides or nucleotides
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines

Family

Application60/612,683Us provisional application · filed 24 Sep 2004

Application11/235,795Continuation · filed 26 Sep 2005

Application13/181,847Continuation · filed 13 Jul 2011

Application14/083,794Continuation · filed 19 Nov 2013

Application14/174,080Continuation

US 2006/0116404 A1Published application

US 2011/0274748 A1Published application

US 2014/0079694 A1Published application

US 8,614,235 B2Related patent

US 2014/0154246 A1This patent

From the US filing history. Foreign family members aren’t listed.

Cai-based systems and methods for the localized treatment of ocular and other diseases

Life of this patent

Cai-based systems and methods for the localized treatment of ocular and other diseases

Life of this patent

Abstract

Claims30