Virus strains
AssigneeAmgen Inc.
InventorRobert S. COFFIN
Life of this patent
Estimating the term…
Abstract
The present invention relates to non-laboratory virus strains, for example of herpes viruses such as HSV, with improved oncolytic and/or gene delivery capabilities as compared to laboratory virus strains.
Claims32
Use of a modified, oncolytic, non-laboratory virus strain in the manufacture of a medicament for the oncolytic treatment of cancer.
Use of a modified, replication incompetent, non-laboratory virus strain comprising a heterologous gene in the manufacture of a medicament for the delivery of said gene to a subject.
21-40. (canceled)
A method of producing a modified non-laboratory virus strain comprising:
- (i) providing a non-laboratory strain of a virus;
- (ii) modifying it to render it replication incompetent and, (iii) inserting a heterologous gene.
(canceled)
A modified, oncolytic, non-laboratory virus strain wherein the virus strain is selected from the group consisting a herpes virus, adenovirus, picornavirus, retrovirus or alphavirus.
A modified non-laboratory virus strain comprising a heterologous gene.
45-55. (canceled)
(canceled)
A method of treating or preventing a central nervous system disorder comprising administering to an individual in need thereof a virus as defined in claim 23.
Dependencies are inferred from the claim text.