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US 2014/0154203 A1Published application
Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using The Same
AssigneePharmaIN Corporation
InventorsGerardo M. Castillo, Elijah M. Bolotin
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Abstract
The present invention relates, in part, to a biocompatible hydrophobic-core carrier comprising a carrier, and a plurality of hydrophobic groups covalently linked to the polymeric carrier. The hydrophobic groups are capable of dissociably linking load molecules such as therapeutic agents. The hydrophobic-core carrier may also comprise protective side chains, orienting molecules, and targeting molecules.
Claims40
1-32. (canceled)
A composition, comprising:
- (i) a carrier;
- and
- (ii) a plurality of first hydrophobic groups with a covalently linked protective side chain, wherein the first hydrophobic group has a first end that is covalently linked to the carrier and a second end that is covalently linked to the protective side chain;
- wherein the first hydrophobic group has a molecular weight between 150 to 1000 Daltons independent of the carrier and protective side chain weights;
- and wherein the protective side chain has a molecular weight between about 400 and 20,000 Daltons independent of the carrier and hydrophobic group weights.
2 more elements
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41-48. (canceled)
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65-78. (canceled)
80-81. (canceled)
84-90. (canceled)
A composition comprising
- (i) a carrier;
- (ii) a plurality of first hydrophobic groups, wherein the first hydrophobic group is covalently linked to the carrier, is capable of binding a load molecule, and has a molecular weight of less than about 1,000 Daltons independent of the carrier weight;
- and
- (iii) a plurality of first protective side chains, wherein, each first protective side chain is covalently linked to the carrier and has a molecular weight between about 400 and 20,000 Daltons independent of the carrier weight, wherein the ratio of the hydrophilic protective side chains to the hydrophobic groups is more than 17:1, whereby the composition is soluble in aqueous buffer.
1 more element
Dependencies are inferred from the claim text.