Formulation and method for the treatment of fungal nail infections
AssigneeInstitute of Technology Sligo
InventorsJohn Reginald Barrett, James Joseph Brennan, Thomas Patrick Patton
Life of this patent
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Abstract
The present invention relates to a formulation and method for the treatment of fungal nail infections, such as those caused by Trichophyton rubrum and/or Aspergillus niger. The formulation of the invention comprises glucose oxidase, D-glucose and hydrogen peroxide in an aqueous solution. Advantageously, the formulation of the invention provides a two-stage hydrogen peroxide release for the treatment of the fungal nail infections.
Claims17
A storage-stable antimicrobial formulation for the treatment of fungal nail infections, comprising;
- glucose oxidase at an activity of at least 10 U per 100 g of the formulation;
- D-glucose from 20 to 85% by weight based on the weight of the total formulation;
- additional sugars selected from one or more of sucrose, fructose or maltose from 5 to 70% by weight based on the weight of the total formulation;
- water from 10 to 20% by weight based on the weight of the total formulation;
- with a pH from approximately 4 to 8
- wherein the formulation provides a two-stage hydrogen peroxide release in which
- (a) storage-stable endogenously produced hydrogen peroxide is bioavailable within the formulation at a level of at least 10 mg per litre for immediate release;
- and
- (b) sustained release of further hydrogen peroxide for at least a twenty-four hour period occurs upon rehydration of the formulation.
A storage-stable antimicrobial formulation for the treatment of fungal nail infections, wherein the formulation has antifungal and sporocidal effects which penetrate into and through the nail plate.
15-18. (canceled)
Dependencies are inferred from the claim text.