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AssigneeStichting Vu-Vumc
InventorsPieter Jacob Klein, Athansios Metaxas, Albert Dirk Windhorst, Johannes Antonius Maria Christiaans, Bart Nicolaas Maria van Berckel
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The invention is directed to a N,N-substituted guanidine compound or a salt or solvate thereof according to formula (1), R1RNC(NH)NR2R3, wherein R1 is methyl and R2 is hydrogen. R3 is a organic group comprising a halogen and thiomethyl substituted phenyl group. R is an organic group comprising a substituted aryl group Z wherein the substituent group is —Y—R4, wherein Y is a heteroatom chosen from the group consisting of O, S and N and R4 is a fluorinated organic group.
A N,N-substituted guanidine compound or a salt or solvate thereof according to formula (1)
A compound selected from 1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine or 1-(2-chloro-5-(methylthio)phenyl)-3-(3-(trifluoromethoxy)phenyl)guanidine or 3-(2-chloro-5-(methylthio)phenyl)-1-(3-hydroxyphenyl)-1-methylguanidine.
A method comprising use of 1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine or 1-(2-chloro-5-(methylthio)phenyl)-3-(3-(trifluoromethoxy)phenyl)guanidine to prepare a 11C labeled 1-(2-chloro-5-(methylthio)phenyl)-3-11C-methyl-3-(3-(difluoromethoxy)phenyl)guanidine or 1-(2-chloro-5-(methylthio)phenyl)-3-11C-methyl-3-(3-(trifluoromethoxy)phenyl)guanidine respectively.
Dependencies are inferred from the claim text.