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US 2014/0150788 A1Published application
Dry Powder For Inhalation
AssigneeJagotec AG
InventorsManfred Keller, Rudi Mueller-Walz
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Abstract
The present invention provides dry powder formulations for inhalation having improved moisture resistance such that the powders maintain a high fine particle dosage or fine particle fraction following storage under relatively extreme temperature and humidity conditions.
Claims13
A dry powder inhaler, comprising
- a) a multidose powder reservoir containing a dry powder comprising:
- i) a pharmaceutically inactive carrier having particles of noninhalable particle size,
- ii) a pharmaceutically active component comprising at least one finely divided pharmaceutically active compound having particles of inhalable particle size, and
- iii) magnesium stearate as a pulverulent material present in an amount of 0.5 to 5% by weight, based on the total weight of the formulation;
- and
- b) means for delivering metered doses of the pharmaceutically active compound for inhalation,
- wherein said dry powder has a fine particle fraction (FPF) and a fine particle dose (FPD), said powder exhibiting improved stability of FPF and FPD following 4 to 10 days of storage at 40° C. and 75% relative atmospheric humidity compared to a reference lacking magnesium stearate as a pulverulent material.
4 more elements
Dependencies are inferred from the claim text.