Devices and methods for puncturing a capsule to release a powdered medicament therefrom

A combination of a capsule and a device for puncturing the capsule to release a powdered medicament therefrom, the combination comprising:

• (a) the capsule comprising:
• opposing domes;
• a cylindrical wall portion defined by a capsule wall radius r measured from a central axis of the opposing domes;
• a volume of at least 0.50 cm3;
• and
• a thickness between 0.08 mm and 0.12 mm;
• and
• (b) the device comprising:
• a chamber for receiving the capsule;
• and
• a mechanism for puncturing at least one hole in only a single dome of the capsule, a center of each hole located within an annular puncture region bounded and defined in the single dome by 0.4 r and 0.8 r, and wherein a total surface area of all puncture holes is (i) between 0.5% and 2.2% of a total surface area of the capsule and (ii) between 3% and 15% of a total surface area of the single dome.