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US 2014/0112881 A1Published application
Crosslinked polymer nano-assemblies and uses thereof
AssigneeUniversity of Massachusetts
InventorSankaran Thayumanavan
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AssigneeUniversity of Massachusetts
InventorSankaran Thayumanavan
Estimating the term…
The invention provides a novel system of nano-assemblies and related method for delivery of therapeutic, diagnostic or imaging agent to biological sites. The compositions and methods of the invention enable the syntheses of novel polymeric nano-assemblies (nanoparticles) under non-emulsion conditions with the incorporation of hydrophobic guest molecules. The versatilities and advantages of the polymer nanoparticles of the invention include: (i) the guest molecules (e.g., drug molecules) can be readily incorporated non-covalently within the nanoparticles; (ii) the surface of the nanoparticles are functionalizable; (iii) the non-covalently encapsulated guest molecule (payload) can be released in response to a biologically relevant stimulus at the target site; (iv) the payload is held by the polymeric nanoparticle before being internalized in cells and can be released within the cellular interiors; (v) encapsulating lipophilic small molecules within its crosslinked interiors and binding proteins on its surface through electrostatic interactions; (vi) facile synthetic methods for ligand functionalization that can be utilized to decorate nanogels with cell targeting ligands that facilitate receptor-dependent cellular uptake, and (vii) the payload release kinetics is tunable and controllable.
A nano-assembly for controlled delivery of a therapeutic or diagnostic agent to a biological site, comprising:
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The nano-assembly of claim 13, wherein each of R2, R′2, R″2, R3, R′3 and R″3 is a hydrogen, and each of R1, R′1 and R″1 is a methyl group.
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A nano-assembly for controlled concurrent delivery of small molecule and non-small molecule therapeutic, diagnostic or imaging agents to a biological site, comprising:
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A method for delivering a therapeutic, diagnostic or imaging agent to a biological site, comprising:
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Dependencies are inferred from the claim text.