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AssigneeChildren's Hopital of Eastern Ontario Research Institute Inc.
InventorDavid F. Stojdl
Estimating the term…
The present disclosure concerns an oncolytic virus for the treatment of cancer, such as in brain cancer, for example glioblastoma. The oncolytic virus may exhibit reduced levels of neurotoxicity. The oncolytic virus may be an isolated viral particle capable of producing a cDNA polynucleotide that includes a sequence according to SEQ ID NO: 1 when the virus is in a host cell. The oncolytic virus may be an isolated viral particle that includes an RNA polynucleotide that includes a sequence according to SEQ ID NO: 2. The oncolytic virus may be an isolated viral particle having a genome that includes open reading frames that encode: proteins having sequences comprising SEQ ID NOs: 3, 4, 5, 6 and 7; or variants thereof.
An isolated viral particle having a genome comprising open reading frames that encode:
An isolated viral particle capable of producing a cDNA polynucleotide when the virus is in a host cell, the cDNA polynucleotide having a sequence comprising:
An isolated viral particle capable of producing a cDNA polynucleotide comprising a sequence according to SEQ ID NO:
An isolated viral particle comprising an RNA polynucleotide comprising a sequence according to SEQ ID NO:
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Dependencies are inferred from the claim text.