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US 2014/0030269 A1Published application
Staphylococcus aureus Specific Human Recombinant Polyclonal Antibodies and Uses Thereof
AssigneeExcelimmune, Inc.
InventorVincent W. Coljee
Life of this patent
Estimating the term…
Abstract
Human antibodies that bind to one or more strains Staphylococcus aureus strains, including methicillin resistant strains, are disclosed. Also disclosed are human recombinant polyclonal antibody compositions, and therapeutic methods for using the antibodies.
Claims21
-44. (canceled)
A method for treating or preventing Staphylococcus aureus (S. aureus) infection in a mammal, the method comprising administering an effective amount of a recombinant monoclonal antibody mixture, wherein the antibody mixture comprises at least two human antibodies, each of which binds to and neutralizes a S. aureus toxin or antigen conserved among at least three different strains of S. aureus;
- and wherein each antibody in the antibody mixture binds an epitope that is not bound by another member of the antibody mixture.
(canceled)
An anti-Staphylococcus aureus (S. aureus) antibody or antigen-binding fragment thereof selected from the group consisting of:
- (a) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 38 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 40 of 5.6.H9;
- (b) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 173 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 175 of 22.18A.E9;
- (c) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 11 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 13 of 5.11.H10;
- (d) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 20 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 22 of 5.27.A11;
- (e) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 47 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 49 of 5.17.F8;
- (f) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 56 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 58 of 5.19.F12;
- (g) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 65 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 67 of 5.23.C9;
- (h) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 74 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 76 of 5.23.C12;
- (i) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 83 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 85 of 8.51.G11;
- (j) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 92 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 94 of 9.51.H9;
- (k) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 101 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 103 of 18.43.D8;
- (l) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 110 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 112 of 22.22.E7;
- (m) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 149 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 151 of 8.51.G10;
- (n) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 153 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 155 of 5.24A.A7;
- (o) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 157 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 159 of 5.24A.F3;
- (p) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 161 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 163 of 5.8B.H4;
- (q) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 165 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 167 of 26.51.E1;
- (r) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 169 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 171 of 22.21.A7;
- (s) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 177 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 179 of 5.52.H10;
- (t) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 181 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 183 of 5.15.C1;
- (u) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 185 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 187 of 5.54.E6;
- (v) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 189 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 191 of 5.55.D2;
- (w) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 193 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 195 of 22.14.A1;
- (x) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 197 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 199 of 26.53.B4;
- (y) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 201 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 203 of 5.63.E2;
- (z) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 205 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 207 of 5.64.G4;
- (aa) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 209 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 211 of 43.52.A11;
- (ab) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 213 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 215 of 43.52.E12;
- and
- (ac) an antibody comprising CDR1, CDR2 and CDR3 of heavy chain amino acid sequence SEQ ID NO:
- 217 and CDR1, CDR2, CDR3 of light chain amino acid sequence SEQ ID NO:
- 219 of 43.62.E2.
85 more elements
An anti-Staphylococcus aureus (S. aureus) human monoclonal antibody selected from the antibodies listed in Table 2.
A monoclonal antibody mixture that neutralizes Staphylococcus aureus (S. aureus) or a toxin, cell surface antigen or immunomodulating agent thereof, the mixture comprising at least two antibodies as set forth in Table 1 and combinations thereof.
Dependencies are inferred from the claim text.