Use of quorum sensing inhibitors and biofilm dispersing agents for controlling biofilm-associated implantable medical device related infections

A method of controlling the formation of a biofilm on an implantable medical device comprising applying a coating on a portion of said device, wherein the coating is selected from the group consisting of a hydrophilic polymer and a hydrophobic polymer, and wherein the coating further comprises an agent that inhibits the formation of biofilms.

A method for manufacturing an implantable medical device comprising:

• forming a housing for the implantable medical device from a biocompatible material;
• and
• applying to an exterior surface of the housing a coating selected from the group consisting of a hydrophilic polymer and a hydrophobic polymer, wherein the coating further comprises an agent that inhibits the formation of biofilms.

An implantable medical device comprising:

• a housing;
• and
• an actuator disposed within the housing, wherein the actuator is configured to deliver to an exterior surface of the housing an agent that inhibits the formation of biofilms, wherein the agent is selected from the group consisting of a quorum sensing inhibitor and a biofilm dispersal agent.