Synthetic genes and genetic constructs
AssigneeCommonwealth Scientific and Industrial Research Organisation
InventorsMichael Wayne Graham, Robert Norman Rice
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Abstract
The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.
Claims5
A synthetic gene which is capable of modifying target gene expression in a cell, tissue or organ of a prokaryotic or eukaryotic organism which is transfected or transformed therewith, wherein said synthetic gene at least comprises a structural gene sequence comprising a nucleotide sequence which is substantially identical to the nucleotide sequence of said target gene or a derivative thereof or a complementary sequence thereto placed operably under the control of a promoter sequence which is operable in said cell, tissue or organ.
2-4. (canceled)
A cell, tissue, organ or organism comprising the synthetic genes and genetic constructs described herein.
Plasmid pEGFP-N1 MCS or a derivative thereof.
7-33. (canceled)
Dependencies are inferred from the claim text.