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US 2013/0296569 A1Published application
Process for the preparation of phosphoric acid mono-(1--4-methoxymethyl-piperidin-4-yl) ester
OwnerVijaykumar Jagdishwar Patil, Rajkumar Vishwanath Hangarge +3inventors
InventorsVijaykumar Jagdishwar Patil, Rajkumar Vishwanath Hangarge, Burhanuddin Munshi Zaki Ahmed, Loganathan Velupillai, Bharat Kalidas Trivedi
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Abstract
The invention relates to a process to prepare pharmacologically active phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluoro phenyl}-4-methoxy methyl-piperidin-4-yl)ester.
Claims10
A Process for the preparation of the Phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl)ester of Formula (A),
- the process comprising the steps of:
- a) Converting intermediate of Formula (1) into intermediate of Formula (3)
- b) Converting intermediate of Formula (3) into intermediate of Formula (5)
- c) Converting intermediate of Formula (5) into intermediate of structure (6)
- d) Converting intermediate of Formula (6) into intermediate of Formula (10)
- e) Converting intermediate of Formula (10) into intermediate of Formula (11),
- f) Converting intermediate of Formula (11) into compound of Formula (A) or Pharmaceutically acceptable salts thereof
4 more elements
A compound selected from the group comprising of:
- 6-(2,6-difluoro-4-nitrophenyl)-1-oxa-6-azaspiro[2.5]octane;
- 1-(2,6-Difluoro-4-nitro-phenyl)-4-methoxymethyl-piperidin-4-ol;
- [3,5-Difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-carbamic acid benzyl ester;
- (5R)-3-[3,5-Difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one;
- (5R)-Methanesulfonic acid 3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl ester;
- (5R)-3-[3,5-Difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-5-azidomethyl-oxazolidin-2-one.
3 more elements
Dependencies are inferred from the claim text.