US 2013/0296414 A1Published application

1-Phenyl-2-Dimethylaminomethyl Cyclohexane Compounds And Therapies For Depressive Symptoms, Pain and Incontinence

AssigneeGruenenthal GmbH

InventorsElmar FRIDERICHS, Wolfgang STRASSBURGER, Ulrich JAHNEL, Helmut BUSCHMANN, Joerg HOLENZ, Oswald ZIMMER, Derek SAUNDERS, Werner ENGLBERGER, Hagen-Heinrich HENNIES

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Abstract

Metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament used for treating depression, and related methods of treating depression, pain and urinary incontinence.

Claims20

Dependent claims

A method of treating depression in a mammal, said method comprising administering to said mammal an effective amount of a compound selected from the group consisting of:

3-(2-dimethylaminomethyl-cyclohexyl)-phenol,
(1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenol,
[2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine,
(1R,2R)-[2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine,
sulfuric acid mono-[3-(2-dimethylaminomethyl-cyclohexyl)-phenyl]ester,
sulfuric acid mono-(1R,2R)-[3-(2-dimethylaminomethyl-cyclohexyl)-phenyl]ester,
3-(2-methylaminomethyl-cyclohexyl)-phenol,
(1R,2R)-3-(2-methylaminomethyl-cyclohexyl)-phenol,
3-(2-dimethylaminomethyl-cyclohexyl)-phenol N-oxide,
(1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenol N-oxide,
6-[3-(2-dimethylaminomethyl-cyclohexyl)-phenoxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid,
6-[(1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenoxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid,
4-(2-dimethylaminomethyl-cyclohexyl)-catechol,
(1R,2R)-4-(2-dimethylaminomethyl-cyclohexyl)-catechol,
3-(2-aminomethyl-cyclohexyl)-phenol,
(1R,2R)-3-(2-aminomethyl-cyclohexyl)-phenol,
4-(2-dimethylaminomethyl-cyclohexyl)-benzene-1,2-diol,
(1R,2R)-4-(2-dimethylaminomethyl-cyclohexyl)-benzene-1,2-diol,
C—[2-(3-methoxy-phenyl)-cyclohexyl]-methylamine,
(1R,2R)—C-[2-(3-methoxy-phenyl)-cyclohexyl]-methylamine,
[2-(3-methoxy-phenyl)-cyclohexylmethyl]-methyl-amine,
(1R,2R)-[2-(3-methoxy-phenyl)-cyclohexylmethyli-methyl-amine,
[2-(3-methoxy-phenyl)-cyclohexylmethyl]-dimethyl-amine N-oxide, and
(1R,2R)-[2-(3-methoxy-phenyl)-cyclohexylmethyl]-dimethyl-amine N-oxide
or a salt thereof with a physiologically tolerated acid.

22 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/935,144Filed 3 Jul 2013
Priority: DE 10233048.419 Jul 2002
Published: 7 Nov 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 31/137
Having aromatic rings , e.g. ketamine, nortriptyline: arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
A61K 31/135
Amines: having aromatic rings , e.g. ketamine, nortriptyline
A61K 31/351
Having six-membered rings with one oxygen as the only ring hetero atom: not condensed with another ring
A61P 13/00
Drugs for disorders of the urinary system

Family

Application11/037,038Continuation · filed 19 Jan 2005
Application13/175,807Continuation · filed 1 Jul 2011
Application13/935,144Continuation
US 2005/0182131 A1Published application
US 2011/0263699 A1Published application
US 2013/0296414 A1This patent

From the US filing history. Foreign family members aren’t listed.

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