Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors

A method of treating a disease associated with the sphingosine-1-phosphate receptor modulation, wherein the disease is selected from:

• ocular diseases, systemic vascular barrier related diseases, allergies and other inflammatory diseases, cardiac diseases or conditions, fibrosis, pain and wounds, which comprises administering to a patient in need thereof, a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof:
• wherein:
• A is a direct bond or (CR) and B, C and D are independently selected from the group consisting of (CR) and N, wherein R is H or alkyl, provided however, not all, of B, C and D are N and, when A is a direct bond, D is (CR),
• R3 is selected from the group consisting of alkyl;
• X is selected from the group consisting of O, NR4 and CR4R5, wherein R4 and R5 are independently selected from the group consisting of H and alkyl;
• Y is selected from the group consisting of O or S;
• and
• Z is a substituted aryl ring.