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US 2013/0296275 A1Published application
Oxazolidinone-quinolone hybrid antibiotics
AssigneeMorphochem Aktiengesellschaft Fur Kombinatorische Chemie
InventorsChristian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Müller, Michael W. Cappi
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Abstract
The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
Claims21
1-18. (canceled)
A compound of formula (I)
- wherein
- A is an alkylene group, an alkenylene group, an alkynylene group, a heteroalkylene group, a cycloalkylene group, a heterocycloalkylene group, an arylene group or a heteroarylene group all of which groups may be substituted;
- Q is CR4;
- X is CR7 or N;
- Y is CR6 or N;
- n is 1, 2 or 3;
- m is 1, 2 or 3;
- R1 is H, F, Cl, Br, I, OH, NH2, an alkyl group or a heteroalkyl group;
- R2 is H, F or Cl;
- R3 is H, an alkyl group, an alkenyl group, an alkynyl group, a heteroalkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, an alkylaryl group or a heteroarylalkyl group;
- all of which groups may be substituted with one, two or more halogen atoms or amino groups;
- R4 is hydroxy, a group of formula OPO3R92 or OSO3R10 or a heteroalkyl group carrying at least one OH, NH2, SO3R10, PO3R92 or COOH group or an ester of a naturally occurring amino acid or a derivative thereof, wherein the groups R9 independently of each other are H, alkyl, cycloalkyl, aryl or aralkyl and wherein R10 is H, alkyl, cycloalkyl, aryl or aralkyl;
- R5 is selected from the following groups:
- R6 is H, F, Cl or OMe;
- R7 is H, F, Cl, OH, NH2, a substituted or unsubstituted alkyl group or a substituted or unsubstituted heteroalkyl group, or
- R3 and R7 can be linked via an alkylene, an alkenylene or a heteroalkylene group or be a part of a cycloalkylene or heterocycloalkylene group;
- in case R3 is no H and R7 is no H, F, OH, NH2 or Cl;
- and
- R8 is a C1-6 heteroalkyl, a heteroarylalkyl, a heteroalkylaryl or a heteroalkylheteroaryl group;
- or a pharmacologically acceptable salt, solvate, hydrate or formulation thereof.
17 more elements
Dependencies are inferred from the claim text.