Pyrrolidinones as metap-2 inhibitors

Compounds of the formula I

• in which
• R1 denotes [C(R4)2]nAr1, (CH2)nHet, (CH2)nCyc,
• or A,
• R2 denotes C(R4)2]nAr2, CH[B(OH)2]CH2Het,
• (CH2)nHet, (CH2)nCyc, CH(C≡CH)phenyl or A,
• R3 denotes OH, Hal, NH2, CN, CF3, CHF2 or N3,
• R4 denotes H or alkyl having 1, 2, 3 or 4 C atoms,
• R2 and R4 together also denote alkylene having 2, 3, 4 or 5 C atoms, where one CH2 group may also be replaced by NH, NA, N—COA, N—(CH2)nAr3, N—(CH2)nHet2, CH-A, CH—O—(CH2)nAr3, N—SO2A or O
• and/or may be substituted by A,
• Ar1 denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, OH, OA, NH2, NHA, NA2, NO2, CN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHSO2A, COA, CHO, Het1, SO2NH2 and/or SO2A,
• Ar2 denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, OH, OA, NH2, NHA, NA2, NO2, CN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHSO2A, COA, CHO, Het1, SO2NH2 and/or SO2A,
• Ara denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, OH, OA and/or A,
• Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, and/or O and/or S atoms which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OH, OA, NH2, NHA, NA2, NO2, CN, COOH, COOA, (CH2)nCONH2, (CH2)nCONHA, (CH2)nCONA2, NHCOA, NHSO2A, COA, CHO, Het1, SO2NH2, SO2A and/or ═O,
• Het1 denotes a monocyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, and/or O and/or S atoms which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OH, OA, NH2, NHA, NA2, NO2, CN, COOH and/or COOA,
• Het2 denotes pyridyl, pyrimidinyl, furyl, thienyl, imidazolyl, pyrrolyl, oxazolyl, oxadiazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl or thiadiazole,
• A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7H atoms may be replaced by F, Cl, Br, OH, CHO, COA, COOA, CN, CONA2, CONHA and/or CONH2,
• and/or in which one or two non-adjacent CH and/or CH2 groups may be replaced by O, N and/or NR4,
• or Cyc,
• Cyc denotes cyclic alkyl having 3-7 C atoms,
• Hal denotes F, Cl, Br or I,
• n denotes 0, 1, 2, 3 or 4,
• and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.