Ngal for diagnosis of renal conditions
OwnerPrasad DEVARAJAN, Jonathan M. Baraschinventors
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Abstract
Use of serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker, alone or in conjunction with creatinine to aid in the diagnosis of renal conditions such as acute tubular necrosis and acute renal failure, and a method and a kit for assigning a diagnosis of acute tubular necrosis or acute renal failure to a subject based on the correlation between the levels of NGAL and optionally creatinine in a sample obtained from a subject when compared to a sample obtained from a normal subject not experiencing acute tubular necrosis or acute renal failure.
Claims11
A method of assigning a diagnosis of acute tubular necrosis to a subject, comprising;
- a) measuring a level of NGAL in a sample obtained from said subject,
- b) comparing the level of NGAL in the sample from said subject with the level of NGAL in a sample from a normal subject, and;
- assigning a diagnosis of acute tubular necrosis when the level of NGAL in a sample obtained from said subject is greater than said normal subject.
A method of diagnosing whether a subject is experiencing acute renal failure or chronic renal failure, comprising;
- a) measuring the level of NGAL in a sample obtained from the subject;
- b) measuring the level of creatinine in a sample obtained from the subject;
- c) correlating the level of NGAL with the level of creatinine, and assigning a diagnosis of acute renal failure or chronic renal failure based on said correlation.
A kit for the diagnosis of acute renal failure or chronic renal failure in a subject, comprising:
- a) a monoclonal antibody that recognises human NGAL;
- b) a tube for collecting a blood sample containing either citrate, EDTA or heparin;
- c) instructions for obtaining an assay result and performing a correlation of assay data to determine whether a subject has acute renal failure or chronic renal failure;
- wherein said instructions further indicate that a high degree of correlation between a NGAL level and creatinine level is indicative of acute renal failure;
- and wherein when there is no correlation between a NGAL level and creatinine level, said instructions indicate chronic renal failure is present.
Dependencies are inferred from the claim text.