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US 2013/0295103 A1Published application
Antibodies against a proliferating inducing ligand (april)
AssigneeBionovion Holding B.V.
InventorsJan Paul Medema, Hans Van Eenennaam, Marco Guadagnoli, Fiona Clare Kimberley, Uyen Truong Phan
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Abstract
The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
Claims19
A binding compound which binds to human APRIL comprising:
- a. an antibody heavy chain variable region comprising at least one CDR selected from the group consisting of SEQ ID NOs:
- 9, 10, 11, 15, 16 and 17, or a variant of any said sequence;
- and/or
- b. an antibody light chain variable region comprising at least one CDR selected from the group consisting of SEQ ID NOs:
- 12, 13, 14, 18, 19 and 20, or a variant of any said sequence.
2 more elements
Dependencies are inferred from the claim text.