Ricin Vaccine and Methods of Making Thereof

An isolated polypeptide comprising, consisting essentially of, or consisting of an amino acid molecule which contains a first sequence that has at least 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, or 100% sequence identity to

• (SS)RTA198:
• (SEQ ID NO:
• 14)
• IFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNX1X2GLPINQRFILVELS
• NHAELSVTLAX4X5X6X1NAYVVGYRAGNSX3YFFHPDNQX2DAEAITHLFTDX3QNRYTFAFGG
• NYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEG
• EMRTRIRYNRRS;
• or
• (SS)RTA1-33/44-198:
• (SEQ ID NO:
• 15)
• IFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTVLPNX1X2GLPINQRFILVELSNHAELSVTLA
• X4X5X6X1NAYVVGYRAGNSX3YFFHPDNQX2DAEAITHLFTDX3QNRYTFAFGGNYDRLEQLAG
• NLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNR
• RS
• wherein both X1's are C, both X2's are C, or both X3's are C,
• X4 is L, F, C, M, A, T, S, W, Y, P, H, E, Q, D, N, K, or R,
• X5 is D, I, V, L, F, C, M, A, G, T, S, W, Y, P, H, E, Q, N, K, or R,
• X6 is V, I, F, C, M, A, G, T, W, Y, P, H, E, Q, D, N, K, or R, and
• wherein when both X1's are C, X6 is not I.