Multispecific epitope binding proteins and uses thereof
AssigneeMedlmmune, LLC
InventorsHerren Wu, Changshou Gao, Carl Hay, Nazzareno Dimasi
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Abstract
The present invention relates to multispecific epitope binding proteins, methods of making, and uses thereof in the prevention, management, treatment or diagnosis of acute or chronic diseases.
Claims21
1-139. (canceled)
An inverted antibody protein comprising at least a first and a second polypeptide chain wherein said first chain is a “light-like” chain comprising at least one antibody heavy chain variable region (VH) linked to a CH1 domain and said second chain is a “heavy-like” chain comprising an antibody light chain variable region (VL) linked to a Ckappa/lambda domain, said Ckappa/lambda region further linked to an Fc region wherein said variable region in said first chain associates with the variable region in said second chain to form an epitope binding site.
Dependencies are inferred from the claim text.