Methods of Producing Adenovirus Vectors and Viral Preparations Generated Thereby
OwnerLivnat BANGIO, Naamit Sher +1inventors
InventorsLivnat BANGIO, Naamit Sher, Eyal Breitbart
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Abstract
The present invention, in some embodiments thereof, relates to methods of producing adenoviruses such as pro- and anti-angiogenic adenovirus vectors and preparations generated there by. Particularly, in some embodiments, the viral vectors comprise a heterologous pro- or anti-angiogenic gene under the transcriptional control of the murine pre-proendothelin promoter (e.g. PPE-1-3X), for targeted expression of in angiogenic endothelium.
Claims25
A method for producing an adenovirus, the method comprising culturing, in a serum-free suspension culture or in an adherent culture, PER.C6 cells infected with an adenovirus comprising a murine pre-proendothelin promoter, whereby said adenovirus is produced.
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