Clip modulation for the treatment of mucosal diseases
AssigneesScott & White Healthcare, The Texas A&M University System
InventorsMartha Karen Newell, Cassie L. Harvey, Richard Tobin
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Abstract
The disclosure relates to methods for treating disorders of the mucosal tract such as the gastrointestinal system by targeting CLIP molecules. The methods are based on that CLIP in the groove of MHC class I or II molecules of the cells lining the mucosal surfaces of the body, such as the gastrointestinal tract, provides protection from MHC Class II or MHC class I mediated cell death, and therefore are useful for treating, inhibiting the development of a multitude of illnesses and conditions of the mucosal tract, including autoimmune disease.
Claims14
A method of protecting a mucosal cell from MHC class I or MHC class II mediated cell death, comprising contacting intestinal epithelial cells with a CLIP inducing agent in an effective amount to place CLIP peptide on the intestinal epithelial cell surface and protect the intestinal epithelial cells from MHC class I or MHC class II-mediated cell death.
2-3. (canceled)
(canceled)
A method of treating a subject having inflammatory bowel disease, comprising administering to the subject a CLIP inducing agent in an effective amount to treat the inflammatory bowel disease.
(canceled)
15-23. (canceled)
Dependencies are inferred from the claim text.