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US 2013/0281676 A1Published application
Antibodies to matrix metalloproteinase 9
AssigneeGilead Biologics, Inc.
InventorsScott MCCAULEY, Maria VAYSBERG
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Abstract
The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), wherein the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).
Claims1
An isolated matrix metalloproteinase 9 (MMP9) binding protein, comprising:
- an immunoglobulin heavy chain polypeptide, or functional fragment thereof, and
- an immunoglobulin light chain polypeptide, or functional fragment thereof,
- wherein the MMP9 binding protein specifically binds to an to epitope of human MMP9 comprising amino acid residues R162, E111, D113, and I198.
Dependencies are inferred from the claim text.