Well-defined oligomers of ubiquitin and ubiquitin-like polypeptides, and methods for preparing same
AssigneeWisconsin Alumni Research Foundation
InventorsEric Strieter, Ellen Valkevich, Robert Guenette
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Abstract
The present technology relates to well-defined oligomers comprising two or more monomers wherein each monomer is independently selected from a ubiquitin polypeptide or a ubiquitin-like polypeptide, and the monomers are covalently linked to each other via a thioether group or groups. Further provided are monomer building blocks and methods of making the monomers and oligomers.
Claims26
An oligomer comprising two or more monomers wherein each monomer is independently selected from a ubiquitin polypeptide or a ubiquitin-like polypeptide, and the monomers are covalently linked to each other via a thioether group or groups.
A ubiquitin or ubiquitin-like polypeptide comprising a carboxy terminal alkenyl group, wherein a cysteine residue replaces at least one lysine residue in the ubiquitin or ubiquitin-like polypeptide.
Dependencies are inferred from the claim text.