Thermo-responsive polymer covalently bound with a peptide
AssigneeSolvay SA
InventorsAlberto Saiani, Aline Miller, Roland Callens, Laurent Jeannin, Wafa Moussa
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Abstract
A thermo-responsive polymer covalently bound with a peptide, wherein the peptide comprises a peptide moiety that is able to self-assemble and a functional peptide moiety comprising a bioactive sequence, and compositions comprising such thermo-responsive polymer covalently bound with a peptide. Methods for the preparation of such thermo-responsive polymers covalently bound with a peptide and the use thereof for the preparation of hydrogels.
Claims20
A thermo-responsive polymer covalently bound with at least one peptide, wherein the peptide comprises a peptide moiety that is able to self-assemble and a functional peptide moiety comprising a bioactive sequence.
The polymer according to claim 19, wherein the peptide moiety that is able to self-assemble into a β-sheet is selected from the group consisting of FEFKFEFK, FEFEFKFK, FDFKFDFK, FDFDFKFK, FEFRFEFR, FEFEFRFR, YDYKYDYK, YDYDYKYK, YEYRYEYR, YEYKYEYK, YEYEYKYK, WEWKWEWK, WEWEWKWK, WDWKWDWK, and WDWDWKWK.
A peptide derivative selected from the group consisting of acrylate-GABA-hRGDWP-FEFEFKFK;
- acrylate-GABA-hRGDWP-FEFKFEFK, wherein GABA is γ-amino butyric acid;
- acrylate-Ava-hRGDWP-FEFEFKFK;
- acrylate-Ava-hRGDWP-FEFKFEFK, wherein Ava is 5-aminovaleric acid;
- acrylate-ε-Ahx-hRGDWP-FEFEFKFK;
- acrylate-ε-Ahx-hRGDWP-FEFKFEFK, wherein ε-Ahx is ε-amino caproic acid;
- acrylate-β-ala-hRGDWP-FEFEFKFK;
- acrylate-β-ala-hRGDWP-FEFKFEFK, wherein β-ala is 3-aminopropionic acid;
- Mpr-hRGDWP-FEFEFKFK;
- and Mpr-hRGDWP-FEFKFEFK, wherein Mpr is mercapto propionic acid.
Dependencies are inferred from the claim text.