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US 2013/0281547 A1Published application
Purified Amphiphilic Peptide Compositions and Uses Thereof
Assignee3D Matrix
InventorsLisa Spirio, Zen Chu
Life of this patent
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Abstract
A plurality of amphiphilic peptide chains having alternating hydrophilic and hydrophobic amino acids, wherein the peptide contains at least 8 amino acids, are complementary and structurally compatible, and self-assemble into a beta-sheet macroscopic scaffold wherein peptide at least about 75% of the chains have the same sequence.
Claims39
A method of promoting wound healing, comprising:
- administering to a wound site in a subject a composition comprising a plurality of polypeptides, which plurality constitutes a pure preparation in that:
- (i) each of the polypeptides in the plurality is at least 8 amino acids long;
- and
- (ii) each of the polypeptides in the preparation has an amino acid sequence comprising RADARADARADARADA (SEQ ID NO:
- 13), or a fragment thereof, wherein the administering is performed such that polypeptides in the plurality assemble into a hydrogel comprising beta-sheets.
2 more elements
A method of promoting wound healing, comprising:
- administering to a wound site in a subject a cell-free composition comprising a plurality of polypeptides, which plurality constitutes a pure preparation in that:
- (i) each of the polypeptides in the plurality is at least 8 amino acids long;
- and
- (ii) each of the polypeptides in the preparation has an amino acid sequence comprising RADARADARADARADA (SEQ ID NO:
- 13), or a fragment thereof, wherein the administering is performed such that polypeptides in the plurality assemble into a hydrogel comprising beta-sheets.
2 more elements
A method of promoting wound healing, comprising:
- administering to a wound site in a subject a composition consisting of a buffer and_a plurality of polypeptides, which plurality constitutes a pure preparation in that:
- (i) each of the polypeptides in the plurality is at least 8 amino acids long;
- and
- (ii) each of the polypeptides in the preparation has an amino acid sequence comprising RADARADARADARADA (SEQ ID NO:
- 13), or a fragment thereof, wherein the administering is performed such that polypeptides in the plurality assemble into a hydrogel comprising beta-sheets.
2 more elements
Dependencies are inferred from the claim text.