Back to results
US 2013/0281518 A1Published application
Method of treating inflammatory lung disease with suppressors of cpg oligonucleotides
AssigneeThe United States of America as Represented by the Secretary of the Department of Health and Human S
InventorsDennis M. Klinman, Hiroshi Yamada
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for inhibiting or treating inflammatory lung disease by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
Claims21
A method of reducing infiltration of neutrophils into a lung of a subject with an inflammatory lung disease, comprising
- administering to the subject with the inflammatory lung disease a therapeutically effective amount of a suppressive oligodeoxynucleotide, wherein the suppressive oligodeoxynucleotide comprises from 2 to 4 guanosine-rich sequences, forms a G-tetrad, is 8 to 100 nucleotides in length, and has a CD value of greater than about 2.9,
- thereby reducing the production of the infiltration of neutrophils into the lung of the subject with the inflammatory lung disease.
Dependencies are inferred from the claim text.