Macrocyclic compounds and methods of treatment
AssigneesUniversity of Florida Research Foundation, Inc., Korea Research Institute of Chemical Technology, Duke University
InventorsHendrik Luesch, Jiyong Hong, Seong Hwan Kim
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Abstract
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating bone processes, and methods of treating bone-related disease, disorders, and symptoms thereof.
Claims23
-7. (canceled)
A pharmaceutical composition comprising the compound of formula I, an additional anti-osteoporotic agent, and a pharmaceutically acceptable carrier:
- each R is independently H or optionally substituted alkyl;
- each R1 is independently H, or optionally substituted alkyl;
- each R2 is independently H, optionally substituted alkyl, or C(O)R;
- each R3 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
- each R4 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
- and pharmaceutically acceptable salts thereof.
-11. (canceled)
A method of modulating the activity of osteoclastic activity in a subject, comprising contacting the subject with a compound of formula I, in an amount and under conditions sufficient to modulate osteoclastic activity in the subject:
- each R is independently H or optionally substituted alkyl;
- each R1 is independently H, or optionally substituted alkyl;
- each R2 is independently optionally substituted alkyl, or C(O)R;
- each R3 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
- each R4 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
- and pharmaceutically acceptable salts thereof.
A method of modulating the activity of osteoblastic activity in a subject, comprising contacting the subject with a compound of formula I, in an amount and under conditions sufficient to modulate osteoblastic activity in the subject:
- each R is independently H or optionally substituted alkyl;
- each R1 is independently H, or optionally substituted alkyl;
- each R2 is independently II, optionally substituted alkyl, or C(O)R;
- each R3 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
- each R4 is independently II, optionally substituted alkyl, C(O)OR, or C(O)NRR;
- and pharmaceutically acceptable salts thereof.
A method of treating a subject suffering from or susceptible to a bone disorder or disease, wherein the subject has been identified as in need of treatment for a bone disorder or disease, comprising administering to said subject in need thereof, an effective amount of a compound of formula I, such that said subject is treated for said disorder:
- each R is independently H or optionally substituted alkyl;
- each R1 is independently H, or optionally substituted alkyl;
- each R2 is independently optionally substituted alkyl, or C(O)R;
- each R3 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
- each R4 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
- and pharmaceutically acceptable salts thereof.
-33. (canceled)
Dependencies are inferred from the claim text.