Thiazole derivatives and their use as p2y12 receptor antagonists

A compound of formula I

• wherein
• R1 represents (C1-C6)alkoxy;
• Y represents a bond and Z represents hydrogen;
• or
• Y represents (C1-C3)alkandiyl and Z represents hydrogen, hydroxy, —COOH, —COOR5, —P(O)(OH)2, —P(O)(OR6)2, —P(O)(NHR7)2 or phenyl, wherein the phenyl is substituted with —P(O)(OH)2 or —P(O)(OR8)2;
• W represents a group selected from
• R2 represents hydrogen;
• halogen;
• (C1-C4)alkyl which is monosubstituted with (C1-C4)alkoxy, —COOH or —COOR9;
• (C2-C4)alkenyl which is monosubstituted with (C1-C4)alkoxy, —COOH or —COOR9;
• phenyl which is unsubstituted or monosubstituted with halogen;
• (C1-C4)alkyl-amino, wherein the alkyl-group is monosubstituted with hydroxy, (C1-C4)alkoxy, —COOH or —COOR9;
• di-(C1-C4)alkyl-amino;
• heterocyclyl which is unsubstituted or monosubstituted with (C1-C4)alkyl or (C1-C4)alkoxy;
• or 2-methoxymethyl-cycloprop-1-yl;
• R3 represents aryl which is unsubstituted or mono- or di-substituted, wherein the substituents are independently selected from the group consisting of halogen, (C1-C4)alkyl, (C1-C4)alkoxy and phenoxy;
• R4 represents halogen;
• (C1-C4)alkyl which is monosubstituted with (C1-C4)alkoxy, —COOH, or —COOR9;
• (C2-C4)alkenyl which is monosubstituted with (C1-C4)alkoxy or —COOR9;
• phenyl;
• or di-(C1-C6)alkyl-amino;
• R5 represents (C1-C4)alkyl;
• R6 represents (C1-C4)alkyl, (C1-C4)alkyl-C(O)—OCH2— or (C1-C4)alkoxy-C(O)—OCH2—;
• R7 represents (C1-C4)alkoxy-C(O)—(C1-C4)alkyl-;
• R8 represents (C1-C4)alkyl;
• R9 represents (C1-C4)alkyl;
• or a pharmaceutically acceptable salt of such a compound.