Methods and compositions for increasing red blood cells
AssigneeAcceleron Pharma Inc.
InventorsRavindra Kumar, Naga Venkata Sai Rajasekhar Suragani, John Knopf
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Abstract
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Claims39
A method for increasing red blood cell levels or treating anemia in a patient, the method comprising administering to a patient in need thereof a polypeptide selected from the group consisting of a BMP9 polypeptide and a BMP10 polypeptide.
A pharmaceutical preparation comprising a BMP polypeptide and a prodomain polypeptide, wherein the BMP polypeptide is selected from the group consisting of:
- a BMP9 polypeptide and a BMP10 polypeptide, and wherein the prodomain polypeptide is selected from the group consisting of a BMP9 prodomain polypeptide and a BMP10 prodomain polypeptide.
The pharmaceutical preparation wherein a substantial portion of the BMP polypeptide is noncovalently associated with the prodomain polypeptide.
Dependencies are inferred from the claim text.