Glucagon-Like Peptide-1 Glycopeptides
AssigneeBiousian Biosystems, Inc.
InventorsEdward Bilsky, Robin Polt, Hanoch Senderowitz
Life of this patent
Estimating the term…
Abstract
A stretching and exercise device has a first strap member having a pair of end portions, a second strap member having a pair of end portions, and a pair of resistance members connected between respective end portions of the first and second strap members. A third strap member has a pair of end portions attached to respective first and second surface portions of the second strap member. A fourth strap member is attached to a third surface portion of the second strap member different from the first and second surface portions thereof.
Claims22
A glycosylated peptide comprising the following amino acid sequence:
- [SEQ ID NO:
- 1]
- H x2 x3 G x5 F T y8 D x10 x11 x12 x13 y14 E x16 y17 A x19 x20 x21 F I y24 W x26 x27
- [[*]]y28 x29 [[*]]y30 - B
- wherein:
- B is selected from NH2 and OH;
- X2=G,S/A;
- X3=E/A;
- X5=T/A;
- Y8=S/A;
- X10=V/L/A;
- X11=S/A;
- X12=S/K/A;
- X13=Y/Q;
- Y14=L/M/A;
- X16=G/E/A;
- y17=Q/E/A;
- X19=A/V;
- X20=K/R;
- X21=E/L/A;
- Y24=A/E/Q;
- X26=L/A;
- X27=V/K/A;
- y28=K/N/E/R/A;
- X29=G/A;
- Y30=R/G/A;
- and wherein at least one of y8, y14, y17, y24, y28 and y30 is glycosylated.
A glycosylated peptide comprising the following amino acid sequence:
- H A E G T F T y8 D V S S Y y14 E G y17 A A K E F I y24 W L V y28 G y30-B [SEQ ID NO:
- 2]
- Wherein B is selected from NH2 and OH;
- Y8=S/A;
- Y14=L/M/A;
- y17=Q/E/A;
- Y24=A/E/Q;
- Y28=K/N/E/R/A;
- y30=R/G/A;
- and wherein at least one of y8, y14, y17, y24, y28 and y30 is glycosylated.
A glycosylated peptide comprising the following amino acid sequence:
- [SEQ ID NO:
- 3]
- H A E G T F T S* D V S S Y L* E G Q* A A K E F I A W L V K* G R* - B
- wherein:
- B is selected from NH2 and OH;
- and wherein at least one of the asterisked amino acids is glycosylated.
A glycosylated peptide comprising an amino acid sequence selected from the group consisting of:
- (SEQUENCE ID NO 4)
- (a)H2N-H A E G T F T S* D V S S Y L E G Q A A K E F I A W L V K G R-amide;
- SEQUENCE ID NO 5)
- (b)H2N- H A E G T F T S D V S S Y L E G Q* A A K E F I A W L V K G R-amide;
- (SEQUENCE ID NO 6)
- (c)H2N- H A E G T F T S D V S S Y L E G Q A A K E F I A W L V K G R*-amide;
- SEQUENCE ID NO 7
- (d)H2N- H A E G T F T A D V S S Y L E G Q* A A K E F I A W L V K G R-amide;
- SEQUENCE ID NO 8
- (e)H2N- H A E G T F T S* D V S S Y A E G Q A A K E F I A W L V K G R-amide;
- SEQUENCE ID NO 9
- (f)H2N- H A E G T F T S D V S S Y L E G A A A K E F I A W L V K G R*-amide;
- SEQUENCE ID NO 10
- (g)H2N- H A E G T F T S D V S S Y L E G Q* A A K E F I A W L V A G R-amide;
- SEQUENCE ID NO 11
- (h)H2N- H A E G T F T S* D V S S Y L E G Q A A K E F I A W L V K G A-amide;
- SEQUENCE ID NO 12
- (i)H2N- H A E G T F T A D V S S Y A E G Q* A A K E F I A W L V K G R-amide;
- SEQUENCE ID NO 13
- (j)H2N- H A E G T F T S* D V S S Y A E G A A A K E F I A W L V K G R-amide;
- SEQUENCE ID NO 14
- (k)H2N- H A E G T F T S D V S S Y L E G A A A K E F I A W L V K G R*-amide;
- SEQUENCE ID NO:
- 15
- (l)H2N- H A E G T F T S* D V S S Y L E G Q A A K E F I A W L V A G A-amide;
- SEQUENCE ID NO:
- 16
- (m)H2N-H A E G T F T A D V S S Y L E G Q* A A K E F I A W L V K G A-amide;
- SEQUENCE ID NO:
- 17
- (n)H2N-H A E G T F T S D V S S Y A E G Q A A K E F I A W L V A G R*-amide;
- SEQUENCE ID NO:
- 18
- (o)H2N-H A E G T F T A D V S S Y A E G A A A K E F I A W L V K G R*-amide;
- SEQUENCE ID NO:
- 19
- (p)H2N-H A E G T F T S* D V S S Y A E G A A A K E F I A W L V A G R-amide;
- SEQUENCE ID NO:
- 20
- (q)H2N-H A E G T F T S* D V S S Y L E G A A A K E F I A W L V A G A-amide;
- SEQUENCE ID NO:
- 21
- (r)H2N-H A E G T F T A D V S S Y L E G A A A K E F I A W L V A G R*-amide;
- SEQUENCE ID NO:
- 22
- (s)H2N-H A E G T F T S* D V S S Y A E G Q A A K E F I A W L V A G A-amide;
- SEQUENCE ID NO:
- 23
- (t)H2N-H A E G T F T A D V S S Y L E G Q* A A K E F I A W L V A G A-amide;
- SEQUENCE ID NO:
- 24
- (u)H2N-H A E G T F T A D V S S Y A E G A A A K E F I A W L V A G R*-amide;
- SEQUENCE ID NO:
- 25
- (v)H2N-H A E G T F T S* D V S S Y A E G A A A K E F I A W L V A G A-amide;
- SEQUENCE ID NO:
- 26
- (w)H2N-H A E G T F T A D V S S Y A E G Q* A A K E F I A W L V A G A-amide;
- SEQUENCE ID NO:
- 27
- (x)H2N-H A E G T F T S* D V S S Y L E G Q* A A K E F I A W L V K G R*-amide;
- wherein at least one of the asterisked amino acids is glycosylated.
A glycosylated peptide comprising an amino acid sequence selected from the group consisting of:
- SEQUENCE ID NO 29
- H G E G T F T S D L S K Q M E E E A V R L F I E W L K N G G P S S G A P P P S*;
- SEQUENCE ID NO 30
- H a E G T F T S D V S S Y L E G Q A A K E F I A W L V K G S*;
- SEQUENCE ID NO 31
- H a E G T F T S D V S S Y L E G Q A A K E F I A W L V K G R S*;
- and
- SEQUENCE ID NO 32
- H Aib E G T F T S D V S S Y L E G Q A A K E F I A W L V K Aib R S*;
- wherein the asterisked amino acid is glycosylated.
Dependencies are inferred from the claim text.