Therapeutic methods for solid delivery
AssigneeFred Hutchinson Cancer Research Center
InventorChristopher Hubert
Life of this patent
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Abstract
A fluid-delivery device includes an array of needles. The needle can deposit a hollow and/or porous tube into a tissue of a subject, and the porous tube can contain one or more fluid agents. The hollow and/or porous tube can control the rate at which the agents diffuse into the tissue. The device can simultaneously deliver a plurality of porous tubes along parallel axes in a tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue; based on the evaluation, candidate agents or subjects can be selected or deselected for clinical trials or therapy.
Claims91
A drug-delivery device for constrained solid delivery of one or more fluid agents to a tissue, comprising:
- i) one or more needles each configured to receive a porous tube;
- and
- ii) one or more porous tubes each configured to contain at least one fluid agent.
A method for spatially restricted solid delivery of one or more fluid agents to a tissue of an organism, comprising the steps of:
- i) inserting one or more porous tubes into a tissue using one or more needles;
- and
- ii) delivering the content of said one or more porous tubes to the tissue at least partially by diffusion through pores of said one or more porous tubes.
A method of rating a candidate agent for development into a therapeutic agent, comprising the steps of:
- i) inserting one or more porous tubes containing one or more candidate agents into a tissue using one or more needles;
- ii) delivering the content of said one or more porous tubes into the tissue at least partially by diffusion through pores of said one or more porous tubes;
- and
- iii) evaluating the effects of said one or more candidate agents on the tissue.
Dependencies are inferred from the claim text.