Back to results
US 2013/0280727 A1Published application
Methods for detecting nucleic acids indicative of cancer
AssigneeExact Sciences Corporation
InventorAnthony P. Shuber
Life of this patent
Estimating the term…
Abstract
The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer.
Claims7
A method for screening a patient for cancer or precancer, the method comprising the steps of:
- detecting in a patient tissue or body fluid sample comprising exfoliated cells and cellular debris, nucleic acid fragments that are greater than 200 base pairs in length;
- the presence of said fragments being a positive screen for cancer or precancer.
A method for screening a patient for cancer or precancer, the method comprising the steps of:
- determining in a patient tissue or body fluid sample a first amount of nucleic acid fragments greater than 200 base pairs in length;
- determining in said sample a second amount of nucleic acid fragments less than about 200 base pairs in length;
- determining a ratio between said first amount and said second amount;
- and
- identifying a positive screen if said ratios exceeds a threshold ratio for patients who do not have cancer or precancer.
2 more elements
A method for screening a patient for cancer or precancer, the method comprising the step of
- detecting in a patient tissue or body fluid sample comprising exfoliated cells a nucleic acid fragment of a length that is not expected to be present in said sample in a healthy patient;
- the presence of said fragment being a positive screen.
Dependencies are inferred from the claim text.